Education
Dr. Azócar obtained his MD from the Central University Medical
School in Caracas Venezuela, and his MSc and a Doctorate in
Science from Harvard University. He did his postdoctoral
training in oncology and hematology at Boston and Brown
universities.
Dr. Azócar is currently Medical Director at Northgate Medical, Springfield MA. He has served at various other hospitals as a primary care and internal medicine physician.
Research
Clinical Research SITE:Principal Investigator,
1.- Therapeutic Vaccine for HIV Clinical Trial (Phase III REMUNE) .
Immuno Research Corporation and Northgate Medical, Springfield, MA
(1996-1999)
2.- Wings. Pegasys/HCV/Roche: 2001- present
3.- Takeda/ Actos: 2001- present
4.- HCV/Recap/ Sherring: 2000-present
Clinical Research SITE: Associated Investigator: Community Research
Initiative of New England
Publications
1. Azocar, J., Essex, M., Susceptibility of Human Cell Lines to
Feline Leukemia Virus and Feline Sarcoma Virus. Journal National
Cancer Institute, 1979 Nov.; 63(5): 1179: 84.
2. Azocar, J., Essex, M., Incorporation of HLA Antigens into the
Envelope of RNA Tumor Viruses Grown in Human Cells. Cancer Res.,
1979, Sep.; 39(9): 3388-91.
3. Azocar, J., Essex, M., Feline Oncornaviruses: Replication in
Human Cells. In: Advances in Leukemia Research. Lapin and Blakeslee,
eds. Elsevier/North Holland, Inc. 1979: 179-84.
4. Azocar, J., Essex, M., Interaction of Feline Leukemia Virus with
Lymphoid Cells. In: Virus Lymphocyte Interactions: Implications for
Disease. Profit, M., ed. Elsevier/North Holland, Inc. 1979: 179-89.
5. Azocar, J., McLane, M.F., Essex, M., Neutralization of Feline
Retroviruses with Antisera to Normal Cells. In: Feline Leukemia and
Sarcoma Viruses. Essex, M., ed. Elsevier/North Holland, Inc. 1980:
481-7.
6. Gazit, E., Azocar, J., Mahoney, R., Watson, A., Dubey, D., Essex,
M., Yunis, E., Modulation of Antigen Expression on Lymphoblastoid
Cell Lines. Transplant Proc.1981 Mar; 13(1pt2): 1002-4.
7. Dubey, D., Staunton, D., Azocar, J., Stux, S., Essex, M., Yunis,
E., Natural Killer Activity Against Retrovirus Infected Cells:
Dichotomy in NK Sensitivity of Infected T and B Cells: Clin Immunol
Immunopathol 1982 May; 23 (2): 215-23.
8.Moake, J.L., Rudy, C.K., Troll, J.H., Weinstein, M.J., Colannino,
N.M., Azocar, J., Seder, R.H., Hong, S.L., Deykin, D., Unusually
Large Plasma Factor VIII:von Willebrand Factor Multimers in Chronic
Relapsing Thrombotic Thrombocytopenic Purpura. NEJM, 1982 Dec 2; 307
(23): 1432-35.
9. Azocar, J., Yunis, E.J., Essex, M., Sensitivity of Human Natural
Killer Cells to Hyperthermia. Lancet, 1982 Jan 2; 1 (8262): 16-7.
10. Lee, T.H., Essex, M., de Noronha, F., Azocar, J., Neutralization
of Feline Leukemia Virus with Feline Antisera to Leukocyte
Alloantigens. Cancer Res 1982 Oct; 42(10): 3995-93.
11. Azocar, J., Essex, M., Watson, A., Gazit, E., Anderson, D.,
Yunis, E.J., Changes in the Expression of HLA and Beta 2
Microglobulin by cultures Lymphoid Cells. Hum Immunol 1982 Dec;
5(4): 283-93.
12. Romet-Lemonne, J.L., McLane, M.F., Elfassi, E., Haseltine, W.A.,
Azocar, J., Essex, M., Hepatitis B Virus Infection in Cultured Human
Lymphoblastoid Cells. Science 1983 Aug 12; 221(4611): 667-9.
13. Azocar, J. Essex, M., Yunis, E.J., Cell Culture Density
Modulates the Incorporation of HLA Antigens by Enveloped Viruses.
Hum Immunol 1983 June; 7 (2): 59-65
14. Azocar, J., Anti-Myeloid-Cell Antibody in Procainamide-Induced
Agranulocytosis (letter). Lancet 1984 May 12; 1 (8385): 1069-70
15. O’Daly, J.A., Azocar, J., Immunological Alterations in Chagas
Disease. Chandra, R.K., ed. In: Critical Reviews in Tropical
Medicine. Plenum Publishing. 1984; 187-99.
16. Azocar, J., Linares, J., Essex, M., Distribution of Antibodies
Against the Human T-Cell Leukemia Virus in Healthy Venezuelan Adults
Acta Cient, Venezuela 1985; 36 (2): 170-2)
17. Correnti, M., Pena, M., Mosca, W., Azocar, J., Tapia, F.J.,
Immunocytochemical Analysis of Lymphocyte Subpopulation in Healthy
Individuals in Venezuela. Acta Cient, Venezuela 1986; 37(2): 221-2
18. Azocar, J., Martinez, C., McLane, M.F., Allan, J., Essex, M.,
Lack of Endemic HIV Infection in Venezuela. AIDS Res Hum
Retroviruses 1987 (summer); 3(2): 107-8
19. Azocar, J., Menendez, C.U., Ramirez, J.L., Hernandez, R.,
Acosta, H., Reumann, W., Rincon-Moralez, F., Estevez, J.A.,
Detection of Human Papilloma Virus Sequences in Uterine Cervix
Lesions in Venezuela. Acta Cient Venezuela1988; 39(2): 171-4
20. Lechin, F., Van Der Di, J.S., Azocar, J., Amat, J., Vitelli, J.,
Martinez, C., Lechin, S., Cabrera, A., Cardenas, M., Villa, S.,
Stress Immunology and Cancer: Effect of Psychoactive Drugs. Arch
Venez de Farmacol y Terapeu. 1987; 3: 107-8
21. Rincon, M.F., Ramirez, J.L., Menendez, C., Azocar, J., Papilloma
Virus DNA Sequences in Invasive Cervical Carcinoma. Arch Venez de
Farmacol y Terapeu 1988; 7:24-32
22. Azocar, J., Abad, S.M., Acosta, H., Hernandez, R., Gallegos, M.,
Pifano, E., Blanch, R., Kramar, A., Prevalence of Cervical Dysplasia
and HPV Infection According to Sexual Behavior. Int’l J Cancer 1990
Apr 15; 45(4): 622-5
23. Roman-Roman, S., Ferradini, L., Azocar, J., Genevee, C.,
Hercend, T., Triebel, F., Studies on the Human T Cell Receptor
Alpha/Beta Variable Region Genes. I. Identification of 7 Additional
V Alpha Subfamilies and 14 J Alpha Gene Segments. Euro J Immunol
1991 Apr; 21(4): 927-33
24. Ferradini, L., Roman-Roman, S., Azocar, J., Michalaki, H.,
Triebel, F., Hercend, T., Studies on the Human T Cell Receptor
Alpha/Beta Variable Region Genes. II. Identification of Four
Additional V Beta Subfamilies. Euro J Immunol 1991 April 21(4):
935-42
25. Ferradini, L., Roman-Roman, S., Azocar, J., Avril, M.F.,
Triebel, F., and Hercend, T., Analysis of T Cell Receptor Alpha/Beta
Variability in Lymphocytes Infiltrating a Melanoma Metastases.
Cancer Rsch 1992. 52: 4649-54
26. James O. Kahan et al. Evaluation of HIV-1 Immunogen, an
Immunologic Modifier, administered to patients infected with HIV
having 300 to 549x10/6 CD4 cell counts. JAMA, 2000; 17:2193-2202.
26. Azocar J, Clavijo Olga, Yunis EJ. MHC Class II Genes in HCV
viral clearance of Hepatitis C Infected Hispanic patients. Hum
Immun. In Press.