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Second level
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Histology
•Fibrosis may exist in an early stage, being confined to the portal tracts, an intermediate stage consisting of expansion of the portal tracts and bridging between portal areas or to the central area, or a late stage of frank cirrhosis characterized by architectural disruption of the liver with fibrosis and regeneration
•Fibrosis can be graded on a scale from 0 to 4
–Stage 0: No fibrosis
–Stage 1: Enlargement of the portal areas by fibrosis
–Stage 2: Fibrosis extending out from the portal areas with rare bridges between portal areas
–Stage 3: Many bridges of fibrosis that link up portal and central areas of the liver
–Stage 4: cirrhosis
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