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Histology
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•Fibrosis may exist in an early stage, being confined to the portal
tracts, an intermediate stage consisting of expansion of the portal tracts
and bridging between portal areas or to the central area, or a late stage of
frank cirrhosis characterized by architectural disruption of the liver with
fibrosis and regeneration
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•Fibrosis can be graded on a scale from 0 to 4
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–Stage 0: No fibrosis
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–Stage 1: Enlargement of the portal areas by fibrosis
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–Stage 2: Fibrosis extending out from the portal areas with rare
bridges between portal areas
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–Stage 3: Many bridges of fibrosis that link up portal and central
areas of the liver
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–Stage 4: cirrhosis
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